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PGx Testing
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Published 24/03/2025
Methotrexate is a drug whose efficacy is affected by our genes. The MTHFR gene can influence folate metabolism and impact Methotrexate (MTX) therapeutic outcome and potential toxicity. Based on my genetic phenotype, I can reveal that I have the G/G variant of MTHFR, meaning that if I needed Methotrexate, I would have a decreased risk of toxicity.
Published 06/02/2025
Methotrexate is commonly used to treat rheumatoid arthritis (RA) by inhibiting dihydrofolate reductase (DHFR), which affects folate metabolism and reduces inflammation. However, its effectiveness depends on how efficiently the body processes folate, which is largely influenced by the MTHFR (methylenetetrahydrofolate reductase) gene.
Published 21/01/2025
As an everyday consumer or patient, you have more control over your medication options than you might think. If you’re dealing with anxiety or depression, drugs like citalopram, escitalopram, and sertraline are commonly recommended. The choice often depends on your symptoms, your history with side effects, potential interactions with other medications, or even foods!
When speaking with doctors in the field of mental health, we’ve identified several recurring themes that highlight the importance of pharmacogenomic testing in the UK. These are: Addressing serious medical conditions, mitigating serious side effects, reducing the financial burden of expensive medications, optimising outcomes when time is limited.
Published 12/12/2024
Pharmacogenomics has emerged as a key component in managing autoimmune diseases, including rheumatoid arthritis (RA), where the immune system attacks its own tissues. These conditions often require complex, long-term treatments. By tailoring drug therapies based on individual genetic profiles, pharmacogenomic testing offers a way to improve patient outcomes while minimising adverse effects.
What is your medical history with ADHD? I have always struggled with organisation, remembering things, and concentration. When I was a child, ADHD wasn’t really recognized in girls, as their hyperactivity tends to manifest as hyperactive thoughts rather than fidgeting. My symptoms became significantly worse when I entered perimenopause, which is apparently common amongst women with ADHD. I suspected I had the condition and confirmed it after sitting in on a friend’s assessment. A year later, I was officially diagnosed.
Published 10/12/2024
Pharmacogenetics (PGx) is transforming the way we approach medicine. This innovative field explores how our genetic makeup influences the way we respond to medications, enabling more personalised treatments. PGx testing has been gaining traction over the past few decades, but where did it all begin, and how has it evolved into the precision tool it is today?
Published 05/12/2024
Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder affecting millions of children worldwide. While medications are often prescribed to help manage ADHD symptoms, the response to these medications can vary significantly among individuals. This variability is where pharmacogenomic (PGx) testing comes into play, offering a powerful tool for personalised medicine that takes genetics into account.
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